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15/06/2015 · Background. Sunitinib is an oral inhibitor of tyrosine kinase receptors implicated in tumor proliferation, angiogenesis, and metastasis. In this randomized, multicenter, open-label Phase IIb study, sunitinib plus mFOLFOX6 oxaliplatin plus leucovorin plus 5-fluorouracil was compared with bevacizumab plus mFOLFOX6 as first-line. 5-Fluorouracil, leucovorin, and oxaliplatin mFOLFOX6 plus sunitinib or bevacizumab as first-line treatment for metastatic colorectal cancer: a randomized Phase IIb study J Randolph Hecht,1 Edith P Mitchell,2 Takayuki Yoshino,3 Manfred Welslau,4 Xun Lin,5 Edna Chow Maneval,6 Jolanda Paolini,7 Maria Jose Lechuga,7 Albrecht Kretzschmar8 1David.

20/05/2016 · SIRFLOX: Randomized Phase III Trial Comparing First-Line mFOLFOX6 Plus or Minus Bevacizumab Versus mFOLFOX6 Plus or Minus Bevacizumab Plus Selective Internal Radiation Therapy in Patients With Metastatic Colorectal Cancer. mFOLFOX6 Plus Panitumumab Versus 5-FU/LV Plus Panitumumab After Six Cycles of Frontline mFOLFOX6 Plus Panitumumab: A Randomized Phase II Study of Patients With Unresectable or Advanced/Recurrent, RAS Wild-type Colorectal Carcinoma SAPPHIRE—Study Design and Rationale. 10/09/2012 · Six patients had grade 4 SAEs, which included infection with or without neutropenia, thromboembolic events, neuropathy, diarrhea, or dehydration. The median number of cycles of mFOLFOX6 plus bevacizumab for patients not having a morbidity event was 11. Considering the promising results of the first line treatment of patients with metastatic colorectal cancer using systemic polychemotherapy plus targeted therapy with median OS ranging from 25 mo to 41.3 mo [27][28][29][30]these regimens have also been used for treating pmCRC. Safety and Efficacy Study of mFOLFOX-6 Plus Cetuximab for 8 Cycles Followed by mFOLFOX-6 Plus Cetuximab or Single Agent Cetuximab as Maintenance Therapy in Patients With Metastatic Colorectal Cancer and WT KRAS Tumours MACRO-2.

15/06/2015 · Background. Sunitinib is an oral inhibitor of tyrosine kinase receptors implicated in tumor proliferation, angiogenesis, and metastasis. In this randomized, multicenter, open-label Phase IIb study, sunitinib plus mFOLFOX6 oxaliplatin plus leucovorin plus 5-fluorouracil was compared with bevacizumab plus mFOLFOX6 as first-line. 5-Fluorouracil, leucovorin, and oxaliplatin mFOLFOX6 plus sunitinib or bevacizumab as first-line treatment for metastatic colorectal cancer: a randomized Phase IIb study J Randolph Hecht,1 Edith P Mitchell,2 Takayuki Yoshino,3 Manfred Welslau,4 Xun Lin,5 Edna Chow Maneval,6 Jolanda Paolini,7 Maria Jose Lechuga,7 Albrecht Kretzschmar8 1David. 20/05/2016 · SIRFLOX: Randomized Phase III Trial Comparing First-Line mFOLFOX6 Plus or Minus Bevacizumab Versus mFOLFOX6 Plus or Minus Bevacizumab Plus Selective Internal Radiation Therapy in Patients With Metastatic Colorectal Cancer. mFOLFOX6 Plus Panitumumab Versus 5-FU/LV Plus Panitumumab After Six Cycles of Frontline mFOLFOX6 Plus Panitumumab: A Randomized Phase II Study of Patients With Unresectable or Advanced/Recurrent, RAS Wild-type Colorectal Carcinoma SAPPHIRE—Study Design and Rationale.

10/09/2012 · Six patients had grade 4 SAEs, which included infection with or without neutropenia, thromboembolic events, neuropathy, diarrhea, or dehydration. The median number of cycles of mFOLFOX6 plus bevacizumab for patients not having a morbidity event was 11. Considering the promising results of the first line treatment of patients with metastatic colorectal cancer using systemic polychemotherapy plus targeted therapy with median OS ranging from 25 mo to 41.3 mo [27][28][29][30]these regimens have also been used for treating pmCRC. Safety and Efficacy Study of mFOLFOX-6 Plus Cetuximab for 8 Cycles Followed by mFOLFOX-6 Plus Cetuximab or Single Agent Cetuximab as Maintenance Therapy in Patients With Metastatic Colorectal Cancer and WT KRAS Tumours MACRO-2. 15/06/2015 · Background. Sunitinib is an oral inhibitor of tyrosine kinase receptors implicated in tumor proliferation, angiogenesis, and metastasis. In this randomized, multicenter, open-label Phase IIb study, sunitinib plus mFOLFOX6 oxaliplatin plus leucovorin plus 5-fluorouracil was compared with bevacizumab plus mFOLFOX6 as first-line.

5-Fluorouracil, leucovorin, and oxaliplatin mFOLFOX6 plus sunitinib or bevacizumab as first-line treatment for metastatic colorectal cancer: a randomized Phase IIb study J Randolph Hecht,1 Edith P Mitchell,2 Takayuki Yoshino,3 Manfred Welslau,4 Xun Lin,5 Edna Chow Maneval,6 Jolanda Paolini,7 Maria Jose Lechuga,7 Albrecht Kretzschmar8 1David. 20/05/2016 · SIRFLOX: Randomized Phase III Trial Comparing First-Line mFOLFOX6 Plus or Minus Bevacizumab Versus mFOLFOX6 Plus or Minus Bevacizumab Plus Selective Internal Radiation Therapy in Patients With Metastatic Colorectal Cancer. mFOLFOX6 Plus Panitumumab Versus 5-FU/LV Plus Panitumumab After Six Cycles of Frontline mFOLFOX6 Plus Panitumumab: A Randomized Phase II Study of Patients With Unresectable or Advanced/Recurrent, RAS Wild-type Colorectal Carcinoma SAPPHIRE—Study Design and Rationale. 10/09/2012 · Six patients had grade 4 SAEs, which included infection with or without neutropenia, thromboembolic events, neuropathy, diarrhea, or dehydration. The median number of cycles of mFOLFOX6 plus bevacizumab for patients not having a morbidity event was 11. Considering the promising results of the first line treatment of patients with metastatic colorectal cancer using systemic polychemotherapy plus targeted therapy with median OS ranging from 25 mo to 41.3 mo [27][28][29][30]these regimens have also been used for treating pmCRC.

Safety and Efficacy Study of mFOLFOX-6 Plus Cetuximab for 8 Cycles Followed by mFOLFOX-6 Plus Cetuximab or Single Agent Cetuximab as Maintenance Therapy in Patients With Metastatic Colorectal Cancer and WT KRAS Tumours MACRO-2. 15/06/2015 · Background. Sunitinib is an oral inhibitor of tyrosine kinase receptors implicated in tumor proliferation, angiogenesis, and metastasis. In this randomized, multicenter, open-label Phase IIb study, sunitinib plus mFOLFOX6 oxaliplatin plus leucovorin plus 5-fluorouracil was compared with bevacizumab plus mFOLFOX6 as first-line.

5-Fluorouracil, leucovorin, and oxaliplatin mFOLFOX6 plus sunitinib or bevacizumab as first-line treatment for metastatic colorectal cancer: a randomized Phase IIb study J Randolph Hecht,1 Edith P Mitchell,2 Takayuki Yoshino,3 Manfred Welslau,4 Xun Lin,5 Edna Chow Maneval,6 Jolanda Paolini,7 Maria Jose Lechuga,7 Albrecht Kretzschmar8 1David. 20/05/2016 · SIRFLOX: Randomized Phase III Trial Comparing First-Line mFOLFOX6 Plus or Minus Bevacizumab Versus mFOLFOX6 Plus or Minus Bevacizumab Plus Selective Internal Radiation Therapy in Patients With Metastatic Colorectal Cancer. mFOLFOX6 Plus Panitumumab Versus 5-FU/LV Plus Panitumumab After Six Cycles of Frontline mFOLFOX6 Plus Panitumumab: A Randomized Phase II Study of Patients With Unresectable or Advanced/Recurrent, RAS Wild-type Colorectal Carcinoma SAPPHIRE—Study Design and Rationale. 10/09/2012 · Six patients had grade 4 SAEs, which included infection with or without neutropenia, thromboembolic events, neuropathy, diarrhea, or dehydration. The median number of cycles of mFOLFOX6 plus bevacizumab for patients not having a morbidity event was 11.

Considering the promising results of the first line treatment of patients with metastatic colorectal cancer using systemic polychemotherapy plus targeted therapy with median OS ranging from 25 mo to 41.3 mo [27][28][29][30]these regimens have also been used for treating pmCRC. Safety and Efficacy Study of mFOLFOX-6 Plus Cetuximab for 8 Cycles Followed by mFOLFOX-6 Plus Cetuximab or Single Agent Cetuximab as Maintenance Therapy in Patients With Metastatic Colorectal Cancer and WT KRAS Tumours MACRO-2.

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